Relationship between Expression Levels and Atherogenesis in Scavenger Receptor Class B, Type I Transgenics
نویسندگان
چکیده
منابع مشابه
Hyperglycemia suppresses hepatic scavenger receptor class B type I expression.
Hyperglycemia is a major risk factor for atherosclerotic disease. Hepatic scavenger receptor class B type I (SR-BI) binds HDL particles that mediate reverse cholesterol transport and thus lowers the risk of atherosclerosis. Here we examined glucose regulation of SR-BI gene expression in both HepG2 cells and whole animals. Results showed that hepatic SR-BI mRNA, protein, and uptake of cholestero...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium.
BACKGROUND AND AIMS Biliary lipid absorption by the gall bladder mucosa and the cholesterol content of the gall bladder wall appear to play a role in cholesterol gall stone formation. As the scavenger receptor class B type I (SR- BI) regulates cellular cholesterol uptake, we studied its expression in human and murine gall bladders, its regulation by increased biliary lipid content, and its role...
متن کاملLiver receptor homolog 1 controls the expression of the scavenger receptor class B type I.
The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human a...
متن کاملDifferentiation-dependent expression and localization of the class B type I scavenger receptor in intestine.
The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells. Results showed that intestinal cells expressed only the SR-BI isoform with little or no expression of the SR-BII variant. The expression of SR-BI in Caco-2 cells is differentiation dependent, with little or no expressio...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m000730200